I am uncertain about the more modern Windows OS like 8.1 and Server 2012. However, auto-tuning did not work correctly in Windows 7 and Server 2008 R2. One of the biggest symptoms was that GUI-based copy/paste between Windows 7 workstations and Server 2008 R2 servers would fail or creep along very slowly (think of copying a file to the company share or your home drive). Disabling auto-tuning, receive-side scaling, and heuristics almost eliminated the issue for me. If your environment consists of these particular operating systems, then you will want to disable auto-tuning, receive side scaling, and heuristics on both the workstations and servers. There is a hotfix but it may be just as easy to either script it or do it manually.

Mar 28, 2019  Windows 10 optimized features in the TCP/IP stack, including CTCP, and TCP Window Auto-Tuning. The new implementation works much better by default than previous Windows versions with broadband internet connections and is able to adjust many values on the automatically. To disable the feature, type the command “netsh int tcp set global autotuninglevel=disabled” into the box on screen (without quotation marks) and hit “Enter” on your computer’s keyboard. The Window Auto Tuning feature will now be disabled.

It is an easy fix and won't interrupt production.

Auto Tuning Video

Auto Tuning.ro

EDIT: Has to be done with elevated privileges.